| abstract |
The present invention relates to certain methods and compositions for diagnosing, preventing, treating, and/or ameliorating the effects of various conditions in a mammal, such as T-cell lymphoblastic leukemia and lymphoma. The present invention also relates, inter alia, to methods of determining whether reducing or blocking NOTCH 1 activation will be effective to treat, prevent, or ameliorate the effects of a cancer in a patient. Such methods may include determining if the patient harbors one or more mutations in exon 28 or intron 27 of the NOTCH1 gene. |