| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efa17ffbbefe213d08a93332c10f524b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_86289527b50fd2a67582530a0dd8d129
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cbe01f0e2d4b35f9073ed256da98752 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24261
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24221 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 |
| filingDate |
2007-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8abf1b341a90e04dfb12fdad176fc2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d4a5847d2ed23c8078d47e2bfd6ee13 |
| publicationDate |
2008-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2009001975-A1 |
| titleOfInvention |
Novel hepatitis c virus mutants having enhanced replication and infectivity |
| abstract |
Disclosed are variants of HCV genotype 2a JFH-I, with enhanced replication and infectivity. Each of the mutants has an amino acid substituted for an amino acid residue located in the C-terminal region of NS5A or in the N-terminal region of NS5B of JFH-1. Compared to JFH-1, the mutant shows alleviated cytotoxicity, but is significantly improved in replication and infectivity. The virus particles produced by the mutant are also highly infectious to hepatic cells and thus can be useful in the development of therapeutic medicines for HCV-induced diseases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9321847-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012133735-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013202598-A1 |
| priorityDate |
2007-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |