| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ee1a36c39bbfaa6382322345904314d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_98ff0aa38a3f2bd2b4e49a1152467ab9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23b7acf5c10289495c288828b462d78b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_534ec727191f84bc365278eb58a3d8a3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2008-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba2c66a6a379af9dc4747dfb0e00e59e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ce89aecfc122c18a254afbb2ddaf1b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af2d96eaf92662c56325a33e45ec74e9 |
| publicationDate |
2008-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008153881-A1 |
| titleOfInvention |
Novel cell-based assays for indentifying enhancers or inhibitors of t1r taste receptors (t1r2/t1r3 sweet) and umami (t1r1/t1r3 umami) taste receptors |
| abstract |
Improved assays for identifying modulators of sweet (TIR2/TIR3) and umami (TIRI/TIR3) taste receptors are disclosed These receptors may be the endogenous TIRs or may be functional variants such as chimeric taste receptors from the extracellular portion of one TIR or a variant or fragment thereof, and the transmembrane portion of another TIR or a variant or fragment thereof, preferably associated with a TIR3 polypeptide and a suitable G protein. The assays preferably use endogenous taste or gastrointestinal cells from mammalian cells or Xenopus oocytes which express TIR taste receptors or recombinant cell which express such TIRs. The modulators identified according to the assays are useful as taste modulators (which is confirmed in taste tests) and/or as therapeutics for treating conditions such as diabetes, obesity weight control, fat metabolism, glucose metabolism, insulin metabolism, satiety and/or the release of satiety peptides such as GLP-1. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2630491-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2630491-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015192664-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104220875-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105381631-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019185387-A1 |
| priorityDate |
2007-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |