| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b309ec7a9d8f0ab1bcc38a5f32e8f2b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03b6a0199fd0816e59d5884312d34d88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_955b1da56c2c772e56663a00a6bcf9d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2f502a965b4c893efb1436714066a8d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-183
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-00 |
| filingDate |
2008-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e9dea6d7e0872bb6916c1626fbd08bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9742157bac03ce8a5d05e56971eb217d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e02be9dbc49d0e1c874c2aeba0e8a3b |
| publicationDate |
2009-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008150479-A3 |
| titleOfInvention |
High temperature stable peptide formulation |
| abstract |
A stabilized pharmaceutical composition in the form of a lyophilized product to be later reconstituted to generate an aqueous drug product is described herein. The therapeutically active ingredient in the form of a peptide of sequence TDLQERGDNDISPFSGDGQPFKD is stabilized with a buffer, carbohydrate stabilizer, a nonionic bulking agent and a surfactant to facilitate reconstitution. The preferred preparation contains a peptide of the sequence TDLQERGDNDISPFSGDGQPFKD, histidine buffer, mannitol or glycine, sucrose and/or Polysorbate 20. This combination of excipients has demonstrated exceptional stability as a lyophilized product when stored at the elevated temperature of 40 °C for at least 6 months and for at least 3 Months at 50 °C. The lyophilized mixture thus formed is reconstituted to a high peptide concentration without apparent loss of stability of the peptide and has also enabled the ability to terminally sterilize the lyophilized product using gamma irradiation without affecting stability. |
| priorityDate |
2007-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |