| abstract |
Disclosed are novel analogues of the natural product radicicol A of formulae I,.Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or prevention of kinase and phosphatase -mediated disorders. Also provided are uses and methods for the treatment or prevention of kinase- and phosphatase -mediated disorders and synthetic processes for the preparation of the compounds. |