| abstract |
Compounds of general formula (1) and pharmacologically acceptable salts and pro-drugs thereof: wherein A and B are CH2 or CH2CH2, R1 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl or heteroaralkyl, D, E and G are CR2 or nitrogen, with the proviso that at least one of D, E and G is nitrogen, R2, R3 and R4 are hydrogen, alkyl, halogen, haloalkyl, alkoxy, alkoxycarbonyl, carboxyl, hydroxyl or cyano, X is R5SO2, R5R7NCO, R5R7NSO2or R5SO2NR7CO, Y is R6CO, R6SO2, R6R7NCO, R6R7NSO2, R6SO2NR7CO or CO2R8, R5 and R6 are hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, R7 is hydrogen, alkyl, aryl or aralkyl, and R8 is alkyl, aryl, aralkyl, alkoxyalkyl, heteroaryl or heteroarylalkyl, are of use inthe prophylaxis or treatment of diseases and conditions in which Kv1.x channels are involved, such as lower urinary tract disorders, cardiovascular diseases, inflammatory and immunological diseases and pain. |