| abstract |
Novel constructs and agents useful for diagnostic and therapeutic applications have been developed. The constructs comprise a chelator, a first linker and either a hydrophobic amino acid or a 'hydrophobe' (hydrophobic non-amino acid), optionally attached to a second linker and a targeting vector. The structure of such compounds enables prolonged residence time in the blood, and therefore increases their usefulness in imaging and treating disease. The present invention is further directed to compounds which provide a high fraction bound to serumand/or to compounds which have high measured relaxivity in Seronorm™. |