http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008141799-A8

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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2304a7c6750a4ee5ebec1df266c7d6eb
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publicationDate 2009-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2008141799-A8
titleOfInvention Oligophosphoramidates
abstract The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. Compounds of Formula (I) are produced.
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