| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a51a1b48dd893c40cef236f4833c689f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df587105262e352f9b434a5417dc06dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec483c1c0056c42c481ab2ca701d1112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff1d23c229049e0b6829881ebe5a2f23 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-10023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5258
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-10022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-10034 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 |
| filingDate |
2007-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df29f7259b5934fcf7039f4f464628fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32ff8dec8ab710df19d7d30be0d0a118
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a172d58482eb3d9bb0d0e2aab5b2520 |
| publicationDate |
2008-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008140610-A2 |
| titleOfInvention |
Antigenicity of infectious pancreatic necrosis virus vp2 sub-viral particles expressed in yeast |
| abstract |
The present invention relates to Infectious Pancreatic Necrosis Virus (IPNV), the etiological agent of infectious pancreatic necrosis in salmonids that causes significant losses in the aquaculture sector. The viral capsid protein (VP2) gene was cloned into a yeast expression vector and expressed in Saccharomyces cerevisiae. Expression of the capsid gene in yeast resulted in the formation of about 20 sub-viral nanoscale particles composed solely of VP2 proteins. Anti-PNV antibodies were detected in rainbow trout vaccinated by injection of purified VP2 subviral particles (rVP2-SVP) or by ingestion of recombinant yeast expressing rVP2-SVP. The provocation test of a trout immunized with rVP2-SVP using a heterologous IPNV strain and the subsequent determination of the viral load showed that the fish vaccinated orally or by injection had lower DPNV loads than the native fish or whose vaccination has been simulated. This study demonstrates the ability of rVP2-SVP to induce a specific immune response and the ability of immunized fish to reduce viral load after experimentally induced IPNV infection. The invention is not limited to IPNV and is applicable to other similar viruses for which subviral particles can be made and administered to fish. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8221767-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9205151-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8329209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8778384-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7998502-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015104551-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3608401-A1 |
| priorityDate |
2006-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |