| abstract |
Disclosed is a compound which has both of a neurite elongation activity and an angiogenesis enhancement activity, and which is applicable to the amelioration of a disease including a head injury or a central nervous system injury (e.g., spinal cord injury), cerebral infarction, an ischemic heart disease (e.g., cardiac infarction, organic angina) and a peripheral arterial disease (e.g., critical limb ischemia), or a sequela of the disease. Specifically disclosed is a compound represented by the formula (I). Preferably, in the formula (I), the group Nx represents an aromatic 6-membered ring having two nitrogen atoms; R0, R1 and R2 independently represent a hydrogen atom, an alkyl group, an amino group or the like; E represents an oxygen atom or a group -NR8 [wherein R8 represents an alkyl group or the like]; n represents an integer of 0 to 5; X and Y independently represent a bond, a cycloalkyl group, -CO- or the like; and Q represents a hydrogen atom or a phenyl group. |