http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008137571-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52cddef51b88e2183dec0b4486186f1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a3e3a63d2234a5800e6e4ed8265d146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dd49d4e7cddb685f52d73fee0b5f289 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2008-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_388b60d1516b79ca6cb2f5dab9dfcfd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9187b32b3f6dbedb99c3993b10659faf |
| publicationDate | 2008-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2008137571-A1 |
| titleOfInvention | Methods of treating neurodegenerative diseases |
| abstract | The invention relates to the discovery that in an animal model of Parkinson's disease (PD), administration of granulocyte colony- stimulating factor (G-CSF) to rodents having 1-methyl~4-phenyl-1,2,3,6-tetrahydropyπdιne (MPTP)-ιnduced PD restores the function of dopamine neurons G-CSF treatment is found to increase the number of dopamine neurons In the substantia nigra (SN), partially restore the nigrostπatal pathway, and restore the function of dopamine to the level before MPTP treatment The invention also relates to the discovery that treatment of a human patient having corticobasilar ganglionic degeneration, or a patient who had suffered an acute stroke, with G-CSF results in a significant improvement in the patient's Unified Parkinson's Disease Rating Scale evaluations and neurological function, respectively The methods described herein can be used to treat PD in a mammalian subject, as well as other neurodegenerative diseases such as Alzheimer's disease, spinal cord injury, and stroke |
| priorityDate | 2007-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.