| abstract |
This present disclosure provides compositions comprising E-10-0H-NT metabolites of AT and NT, methods for their synthesis and methods for their use In one embodiment, the compound (-)-E-5-(y-bromoρropylidene)-10,11-dιhydro-IO-hydroxy-5H-dibenzo[a,d]- cycloheptene. Is prepared by reducing E-5-(y-bromopropylidene)-10,11dιhydro-IO-oxo-5H-dιbenzo[a,d] ?cycloheptene in the presence of a crural-specific oxazaborolidine catalyst In another embodiment, method for inhibiting uptake of norepinephrine comprising contacting a norepinephrine transporter with a composition comprising E-IO-OH-NT that is enriched in the (-) enantiomer Is described |