| abstract |
The present invention is directed to methods to predict the responsiveness of a patient to a TNF blocking drug comprising the steps of: a) assessing in a synovial sample from said patient at least two genes or a fragment thereofs or proteins encoded by said at least two genes, wherein said genes or fragment thereof is as defined in claim 1, and b) predicting the response to the treatment with the TNF blocking agent in said patient by evaluating the results of step (a). The invention is also directed to kits for predicting the response to a treatment with a TNF blocking agent comprising a low density microarray comprising probes suitable for hybridizing with at least two genes or fragments thereof as defined in the claims. |