| abstract |
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of an inflammatory condition, in particular asthma. The compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof: wherein: X and Y are independently selected from-CH2-or-CH2-CH2; Z is seleceted from S(O)m or Se(O)m and m is 0, 1 or 2; R1 is optionally substituted heteroaryl or heterocyclic; R2 is selected from the group consisting of hydrogen, C1 -C6 straight alkyl, and C1 -C6 branched alkyl, wherein all may be optionally substituted; and R3 and R4 are alkyl. |