http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008129562-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_234b0be81a66109f82a02a23a59c1d64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d893517a120df5e7603f09b3c3c010d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_451aedcd267f64ee58df094bf22be0f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75361dbce985e566043dcc2bce25bd13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-36 |
| filingDate | 2008-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b9f6a4e1987aecc3d7059f9ec975511 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46aed399fc2303eae0397b62cb07f03e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc8ca842238b9cf943824403f223f3a1 |
| publicationDate | 2009-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2008129562-A3 |
| titleOfInvention | An improved process for the preparation of stable amorphous atorvastatin hemi calcium and their salts thereof |
| abstract | The present invention describes the preparation of highly pure (i.e. filling in ICH quality parameters with respect to related substances) stable amorphous Atorvastatin calcium salt comprising (a) hydrolysis of 1,3-dioxane ring of (4R-Cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1lH-pyrrol-1-yl]ethyl]-2,2- dimethyl-1,3-dioxane-4-acetate having formula I, (b) in situ hydrolysis of t-butyl group to form Atorvastatin sodium salt solution (c) addition of a single or a mixture of two or more antioxidants and optionally an amine (d) addition of Atorvastatin sodium salt solution to an aqueous solution of calcium acetate or calcium chloride (e) optionally seeding with amorphous atorvastatin calcium (f) filtration and washing of obtained cake using different solvents mixtures in presence of antioxidants (g) dissolving above cake in a solvent or a mixture of two or more organic solvents followed by crystallization of product using an antisolvent. |
| priorityDate | 2007-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.