| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8d0614ef349dba864e03eb44e28aec6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0497abcba37bc761df1c963607f8da89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d031b2a20fae2a3ac6715c47fcd0b440 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y201-01045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2008-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae8899650e575889f54be8ee9ef9d87f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aed8ff6a966f945f4641726ef0d230c9 |
| publicationDate |
2008-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008124927-A1 |
| titleOfInvention |
Sirna against thymidylate synthase and uses thereof in cancer treatment regimens |
| abstract |
Small interfering RNA (siRNA) molecules that target a mammalian thymidylate synthase gene (TS), and which are capable of inhibiting the expression of their target gene, are provided The siRNA molecules are also capable of sensitizing cells to the effects of other anti-cancer agents, particularly chemotherapeutic agents that target TS Methods of treating cancer using the TS siRNA in combination with another anti-cancer agent are also provided Methods of enhancing the effect of a TS siRNA on cancer cell proliferation by combining the TS siRNA with a siRNA targeting a cell survival gene such as Bcl-2 are further provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8524876-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2415870-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20110135980-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2415870-A1 |
| priorityDate |
2007-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |