http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008124098-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_949aef206cffaa3ff153e8dc22e5b2c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa0421b64501ad28c8c0aec3f70d4b21 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2828 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2008-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7e44778566f1bb69cd7f0fbbc75f621 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53abc4300604a24cd8f39c9171ebc82c |
| publicationDate | 2008-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2008124098-A1 |
| titleOfInvention | Prion assay |
| abstract | The invention relates to an assay method for detecting the presence of PrPSc using at least one sequence-specific protease for a substantially complete digestion of the proteins in a sample, leaving the octarepeat region in both PrPSc and PrPC intact, leaving the protease-resistant core of PrPSc intact and remain connected to the octarepeat region, while digesting away at least part of the amino acid sequences in PrPC corresponding to the protease-resistant core in PrPSc. The method further comprises a step of inhibiting further digestion by the protease, a step of denaruration, and a step of detecting the presence of PrPSc using at least two binding partners, a first binding partner and a second binding partner, wherein the first binding partner specifically binds an epitope in the amino-proximal region, and the second binding partner specifically binds an epitope within a region of the protease-resistant core of PrPSc that has been cleaved away in PrPC. The invention also relates to a kit comprising reagents that can be used in the assay method. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018215568-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010084201-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3406632-A1 |
| priorityDate | 2007-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 293.