| abstract |
Fast release or modified release oral compositions containing as the active principle Tacrolimus and/or derivatives thereof in amorphous form, and: a) a 'solubilising agent' of the active principle suitable to maintain it in the amorphous form over time, b) at least one 'diluting agent' having the function to stabilize the active principle in the amorphous form, c) at least one agent being 'modulator' of the dissolution rate of the active principle from the pharmaceutical form. These compositions in form of paste, granules, powder, solution, suspension can be formulated in hard or soft gelatine capsules or can be formulated in other pharmaceutical forms for oral use. These compositions are characterized in that all the relative operations of preparation are carried out in the absence of water and/or organic solvents. |