| abstract |
The present invention relates to a human neural stem cell secreting SMAC, a preparation method thereof and a use thereof, more particularly to a human neural stem cell secreting SMAC transformed by a SMAC-encoding nucleotide, a preparation method thereof and a use thereof. The SMAC secreting human neural stem transformed by a SMAC encoding nucleotide provided by the present invention proliferates and grows on a plate in undifferentiated state, without inducing cytotoxicity, and is capable of differentiating into nerve cells such as neuron, oligodendrocyte and astrocyte in vivo and in vitro. Further, the neural stem cell of the present invention secretes SMAC in the human body and assists the action of TRAIL, thereby inducing apoptosis of tumor cells and reduction of tumor volume. Accordingly, the neural stem cell of the present invention can be effectively used for the treatment or prevention of tumors. |