| abstract |
The invention relates to novel substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles, to the pharmaceutically acceptable salts and/or hydrates thereof, to methods for the production and the use thereof in the form of biologically active substances, to novel pharmaceutical compositions and medicinal agents which are based thereon, exhibit antihistamine activity and contain, in the form of an active substance, substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles and the pharmaceutically acceptable salts and/or hydrates thereof and to the to methods for the production and the use thereof. The novel substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles and the pharmaceutically acceptable salts and/or hydrates thereof correspond to general formula 1.1, 1.2 or 1.3, wherein, in the compounds of 1.1, R1 is an amino group substituent selected from hydrogen or optionally substituted C1-C5 alkyl; R2 is a hydrogen atom or C1-C4 alkyl; R3i is one or more similar or different substituents selected from hydrogen, halogen, C1-C3 alkyl or CF3; n=0 or 1-3; in the compounds of 1.2, R1 is an amino group substituent selected from hydrogen or optionally substituted C1-C5 alkyl; R3i is one or more similar or different substituents selected from hydrogen, halogen, C1-C3 alkyl or CF3 and Ar1 is aryl or heterocyclyl containing at least one carboxylic and/or alkyloxycarbonyl substituent or R3i is a carboxylic and/or alkyloxycarbonyl substituent, and Ar1 is optionally substituted aryl or heterocyclyl; in the compounds of 1.3, R2 is an a hydrogen atom or C1-C4 alkyl; R3i is one or more similar or different substituents selected from hydrogen, halogen, C1-C3 alkyl or CF3 and Ar2 is optionally substituted aryl or heterocyclyl; k=0 or 1-4; m=1 or 2. |