| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1763f7f78d01cad638210d060676591a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-203
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-206
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate |
2008-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c24fc7144be968a31e45ef7f79c4cf21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_003d5a7cd38662ae7699edcd4603474b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b13cca248a0146aca2049fe802d8ddd5 |
| publicationDate |
2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008112542-A1 |
| titleOfInvention |
Methods for conditional and inducible transgene expression to direct the development of stem cells |
| abstract |
Methods are disclosed in which the expression of a specific gene, or combinations of genes, is controlled spatially and temporally to develop intra- and interspecies chimeras. A transgenic EC/ES/P/iPS cell line is created which conditionally expresses a suicide or compromiser gene configured to compromise all cell lineages except that corresponding to a target tissue/organ. The EC/ES/P/iPS cell line is injected into donor embryos having a specific target gene deficiency or embryos genetically engineered to be complementary compromised in lineages corresponding to the target tissue/organ cell lineages of the EC/ES/P/iPS line. One or more stimuli is provided to the embryo to activate compromiser genes for ablation of non-target tissues/organs of the EC/ES/P/iPS line and target tissues/organs of the host embryo, resulting in a chimeric animal having target tissues/organs derived from the genotype of the transgenic cell line and all remaining tissues/organs derived from the donor embryo. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2490443-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2258166-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015197639-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101613717-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2258166-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009114400-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2475656-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2490443-B |
| priorityDate |
2007-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |