| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b37880d2181309a6f74d1d3eabebbb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39a7e3475c20bc718ea3ce38a936ff30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24ce93992ccccfac9ccf6e7f2428f3a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e3e5e978b8fa09e0e393baa9a9914d57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2008-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c5e0aeafcd05397e7b1df3e8e7b3925
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d99ef516d39a23049786ca1d0b5ef813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abcdd85a6c08da164bf3066484e482ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08a80a06ad22194ed9c5c23e52dfa098 |
| publicationDate |
2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008110285-A1 |
| titleOfInvention |
Fluorescence-based assay for detecting compounds for modulating the sodium-calcium exchanger (ncx) in “forward mode” |
| abstract |
Carriers are an up-and-coming target family with enormous potential and offer commercial and scientific possibilities. The sodium/calcium exchanger is an important mechanism for the removal of Ca<SUP>2+</SUP> from various cells. In the heart, said sodium/calcium exchanger extrudes Ca<SUP>2+</SUP>, which has entered through Ca<SUP>2+</SUP> channels for the initiation of contractions, while Na<SUP>+</SUP> enters the heart cell. It is of considerable interest to identify compounds that modulate the activity of the sodium-calcium exchanger. The present invention relates to a fluorescence-based assay for the detection of compounds for modulating the NCX in "forward mode." The invention further relates to a parts set comprising cells that express NCX and to the use of said parts set for testing a compound for activity as an agonist or antagonist of NCX. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011007741-A |
| priorityDate |
2007-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |