| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e0b21d79928bdcb178cb20579e6dce8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f945bcdcdb163ce46bc09426838c91d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5c2d6a5a07914730d77e365aec0bf14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90befd70cbb355a9b004758a6bde720d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01031 |
| filingDate |
2008-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4b6aad748e9ad0cef0801336e779706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6fd5a9c2eb847ada0cd24c87573d936
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abe29e3e01748a9a88cb73133f850823 |
| publicationDate |
2008-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008109677-A2 |
| titleOfInvention |
Modified enzyme and treatment method |
| abstract |
There is disclosed an isolated, modified recombinant β-glucuronidase wherein the modification is having its carbohydrate moeties chemically modified so as to reduce its activity with respect to mannose and mannose 6-phosphate cellular delivery system while retaining enzymatic activity Also disclosed are methods for the treatment of lysosomal storage disease in mammals wherein the mammal is administered a therapeutically effective amount of isolated, modified recombinant β-glucuronidase whereby said storage diseased is relieved in the brain and visceral organs of the mammal. Also disclosed are other lysosomal enzymes within the scope of the invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3401325-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106414727-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2708026-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017055570-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017055586-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2015239126-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11708569-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108291246-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015150490-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020047282-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9982243-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017514462-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019145500-A1 |
| priorityDate |
2007-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |