| abstract |
The invention is directed to methods of modulating an immune response in an animal, comprising administering a composition comprising one or more soluble CDId complexes, in particular non-specific soluble CDId complexes. Soluble CDId complexes comprise a soluble CDId polypeptide, a β2-microglobulin polypeptide, and a ceramide-like glycolipid antigen bound to the CDId antigen binding groove, and in certain embodiments, an immunogen. The administration of compositions of the present invention affects the activity of CD Id-restricted NKT cells, and in particular, allows for multiple administrations without causing CD Id-restricted NKT cell anergy. |