| abstract |
The invention relates to indole derivative having the general Formula (I) wherein A represents a 5-membered aromatic heterocyclic ring, wherein X1, X2 and X3 are independently selected from N, O, S and CH;Y represents CH2, O, S or SO2;R1 is H, (C1-4)-alkyl, (C1-4)alkyloxy, CN orhalogen;R2, R2 ', R3, R3 ', R4,R4 ', R5 and R5 ' are independently hydrogen, (C1-4)alkyl (optionally substituted with OH) or CO-OR8; orone pair of geminal substituents R3 and R3 ' or R5 and R5 ' together represent a keto group, and the others are all hydrogen or (C1-4)alkyl; or R2and R5 together represent a methylene or an ethylene bridge, and R2 '2, R3, R3 ', R4, R4 ' and R5 ' are hydrogen; n is 1 or 2; R6 is H, (C1-4)alkyl (optionally substituted with OH, (C1-4)alkyloxy, CO-NR9R10, CO-OR11or 1,2,4-oxadiazol-3-yl), SO2NR12R13or COOR14; R7 is H or halogen; R 8 is (C1-4)alkyl; R9and R10are independently hydrogen, (C1-4)alkyl or (C 3-7)cycloalkyl, the alkyl groups being optionally substituted with OH or (C1-4)alkyloxy; R11is H or (C1-4)alkyl; R12 and R13 are independently H or (C1-4)alkyl; R14is (C1-6)alkyl; or a pharmaceutically acceptable salt thereof,as agonists of the cannabinoid CB1 receptor, which can be used in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis. |