| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8727215c1a9b846b791f689f528d9a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72593c1d51eb9ce7894d55914ebffc5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5252d2f1de75e197ddac560669b3a7f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4048b1bf129d445c6140a31257fa166a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58208ab3eaa6ff0f83dccfa55616836f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59d436c15ba53ec706310756b5a05127 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2008-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8758b8ea32f91407c610a92a4a77a5b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e19b1621f163a5a376c4912e769e289
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96a70a2f8aea65103f751ef267f972c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e845af9359a781f50188fd2f992b76d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a992f3f9b19ae799247f091f64112be |
| publicationDate |
2008-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008101087-A1 |
| titleOfInvention |
Compositions and methods for modulation of pdx-1 |
| abstract |
Methods and compositions for inhibiting PDX-1 are provided according to the present invention. An anti-PDX-1 agent included in inventive methods and compositions includes an antibody, an aptamer, an antisense oligonucleotide, a ribozyme and/or an inhibitory compound. Methods of inhibiting PDX-1 expression in a tumor cell are provided by the present invention which include contacting a tumor cell with an effective amount of an anti-PDX-1 agent highly or completely complementary to a specified region of an RNA molecule encoding PDX-1. Such an anti-PDX-1 agent specifically hybridizes with the RNA molecule encoding PDX-1 and inhibits the expression of a PDX-1 gene in the tumor cell. Compositions including anti-PDX-1 siRNA and/or shRNA are described. Recombinant expression constructs encoding anti-PDX-1 siRNA or shRNA according to the present invention are described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9133459-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102782139-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8361983-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108118055-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108118055-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2010313441-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011286979-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013509183-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I418369-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011117183-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10253331-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102782139-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014207907-A |
| priorityDate |
2007-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |