| abstract |
Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds of formula (I) are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. Formula (I), wherein: R1 and R2 taken together with the nitrogen to which they are attached form a monocyclic heterocycloalkyl group; wherein: R1 and R2 taken together with the nitrogen to which they are attached form a monocyclic heterocycloalkyl group, optionally containing one additional heteroatom ring member that is O, S, SO2, or NRa, and being unsubstituted or substituted with one, two, or three Rb substituents; and wherein R3-R8, Ra, Rb and n are as defined herein. |