| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a03b4f5d2dd19aab6f44059ad11bbdf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a8dcbd2b5d3804e2cffeced512c1846
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf5047083f91eb7e2af9f3bb40eeb68f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68259edc3d758f5db08ac603576f9772
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_812f82ca5c203e61e948f2a40585c79b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6807
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate |
2008-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89305250a6fd4d346d4ad6fef0215607
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b2e49c8c22d10e43d9a9c012cf4f5ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fad03165bf57790b642452b172bac526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0de24e6e9ae0c7d9b96fca3951a989db |
| publicationDate |
2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008095096-A9 |
| titleOfInvention |
Let-7 microrna and mimetics thereof as therapeutics for cancer |
| abstract |
The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9365852-B2 |
| priorityDate |
2007-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |