| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d5b9a877a8dff02e5a64ed600f179be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0eff49f940720b51169cb9d9bde8c5ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_16df50881c7aea80087a56b247e0f3f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_974e16f1972b5bb61776ccc1a72a99a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2174dd7ac8f6855b2b6a2019d2e222ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1ae3f40beb2f39231bcf15a107b46fa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-12011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1131
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8283 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate |
2008-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73aea30ed318c78d99cb6ab7d5d82276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc450fbbc00632d3a385693ce0181a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c31a1f7d0fa5bf48ae2f298d8ec9153
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0425167733c4889b53e8f62c5c63023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c583a95550b7a59b2aacbfeef28f080 |
| publicationDate |
2008-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008093283-A2 |
| titleOfInvention |
Use of double stranded rna hairpin duplexes in gene silencing |
| abstract |
A DNA polynucleotide is described herein having a modified sequence of a target gene, wherein any one type of nucleotide in the target gene sequence has been chemically modified to another type of nucleotide; and a complementary sequence of the unmodified target gene; wherein either one of the modified sequence or the complementary sequence is in a reverse orientation to the other sequence; and wherein the RNA sequence transcribed from the DNA polynucleotide forms a duplex between the modified sequence and the complementary sequence so that a long double stranded RNA (IdsRNA) duplex forms between the modified and complementary sequences with base pair mismatches where the nucleotides have been modified, the IdsRNA duplex being capable of inhibiting expression of the target gene. RNA polynucleotides and IdsRNA duplexes transcribed by the DNA polynucleotide are also described, as is a method for producing the IdsRNA duplexes. These IdsRNA duplexes can be used in gene silencing. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020536506-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11291357-B2 |
| priorityDate |
2007-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |