| abstract |
The invention provides novel recombinant Gβ5 complex proteins, novel methods of identifying compounds that modulate the conformation of Gβ5 complex, novel methods of treating disorders, including neurological disorders and obesity, with modulators of Gβ5 complex activity, and a mouse model of obesity, where the expression level of Gβ5 complex is reduced by targeted deletion of one allele of a gene encoding a member of the Gβ5 complex. |