| abstract |
A process for the preparation of unsymmetrical biaryl compounds of Formula (I) wherein, R is alkyl, R' is cyano, protected or unprotected tetrazole, or Formula (a) wherein, R' is alkyl, aryl, aralkyl or alkoxy, said process comprising, reacting Grignard reagent of Formula (II) wherein, R is alkyl; X is halogen with an aryl halide of Formula (III) wherein, X is halogen; R' is a cyano, protected or unprotected tetrazole, or Formula (a) wherein, R' is alkyl, aryl, aralkyl or alkoxy in a suitable solvent in the presence of a palladium catalyst and a ligand and Lewis acid as a co catalyst. |