| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4cdd246bafdb8cfc370a4e91cccc41f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_327804b51d47ff6afc403138b838f3f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be1576bcc6db6f7eae1e1e5d76265e15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0bde7a72861bcc4d71bb05dd659716e9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate |
2007-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a9d7ce07207a75068413de5c515e9e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11d0ceceb1ea1c63600eed6a5adfb0ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5207f594db3a28f42a31573a3e376c40 |
| publicationDate |
2008-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008080291-A1 |
| titleOfInvention |
Poly(glutamic acid)-drug conjugate with an amino acid as a linker |
| abstract |
A poly(glutamic acid)-drug conjugate with an amino acid as a linker, and nontoxic pharmaceutically acceptable salt thereof, are provided in the present invention. The drug is gemcitabine, paclitaxel or docetaxel. The α-carboxyl group in the amino acid is linked to 5'-hydroxy in gemcitabine molecule or linked to 2'-hydroxy in paclitaxel (docetaxel) molecule via an ester linkage. The α-amino group in the amino acid is linked to the carboxyl group in the poly(L-glutamic acid) molecule via an amide linkage. The content of gemcitabine in the conjugate is 5-30% in weight, and the content of paclitaxel or docetaxel is 10-40% in weight. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8956613-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9085605-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9890189-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9540410-B2 |
| priorityDate |
2006-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |