| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c39290986c09ef590e9ed4ede97a11b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0451f849a1446d3ad859169d7139a07c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate |
2007-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56c1473683cbafa2d8c7ae2df5ab0a4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_667506d4becd3c399a51a12d97980218 |
| publicationDate |
2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008077062-A2 |
| titleOfInvention |
Suppression of stat3 reactivation after src kinase inhibition to treat cancer |
| abstract |
Methods of treating cancer are disclosed that comprise administering an inhibitor of SFK in a therapeutically effective amount to the subject wherein STAT3 is durably inhibited. The methods include the administration of an SFK inhibitor in combination with a suitable inhibitor of STAT3 reactivation including a STAT3 inhibitor, a JAK inhibitor or any molecule that inhibits STAT3 reactivation or the compensatory pathway for cell survial after inhibition of the SFK. Also provided are therapeutic compositions comprising an SFK inhibitor in combination with at least one inhibitor of STAT3 reactivation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10377731-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2370082-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299469-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2200431-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2200431-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10851075-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011101806-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3067054-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9732055-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10646464-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113082036-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10543189-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8685941-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2370082-A1 |
| priorityDate |
2006-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |