| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b7dea74ff46ca7761dabe6c4d700572c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_226c042b426582e339ebb64ddfab1cbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19946a5c89d1132cecf0a5e4dea10d03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_675f906d7df665aab8189c2b96f668a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-164 |
| filingDate |
2007-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3dfa1ea8cb90f8280d1bf08d4ad59aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efde182d2173dd29e18dc303a1e64ce0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f504a234cfcdb3983a3ba5dfb0b2595
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d61570b515e023a801b111cbda8dd3f2 |
| publicationDate |
2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008076939-A2 |
| titleOfInvention |
Human cancer therapy using engineered matrix metalloproteinase-activated anthrax lethal toxin that targets tumor vasculature |
| abstract |
The present invention provides methods for inhibiting tumor associated angiogenesis by administering a mutant protective antigen protein comprising a matrix metalloproteinase-recognized cleavage site in place of the native protective antigen furin-recognized site in combination with a lethal factor polypeptide comprising a protective antigen binding site. Upon cleavage of the mutant protective antigen by a matrix metalloproteinase, the lethal factor polypeptide is translocated into cancer and endothelial cells and inhibits tumor associated angiogenesis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014031861-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3337498-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015040415-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10568929-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11013784-B2 |
| priorityDate |
2006-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |