| abstract |
A deoxycytidine kinase inhibitor of formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: L1 is a bond (i.e., the nitrogen is directly bound to A), -C(O)-, -SO2-, or -C(R4)2-; A is optionally substituted alkyl, aryl or heterocycle; R1 is hydrogen, halogen, -OH, -NH2, -NO2, -CN, -C(O)OR4, or optionally substituted alkyl; R2 is hydrogen, halogen, -OH, -NH2, -NO2, -CN, -C(O)OR4, or optionally substituted alkyl; each R3 is independently =O or optionally substituted lower alkyl; each R4 is independently hydrogen or lower alkyl; n is 1-3; and m is 0-3 if n is 1, m is 0-4 if n is 2, or m is 0-5 if n is 3, for the treatment of cancer. |