| abstract |
The present invention relates to thiol derivatives of formula I for immobilization linker for biomolecules: R -(CH2)n-(OCH2C Η2)m-OC O Z-Q (i) wherein R is thiol; Z is C1C12 alkylene or; Q is selected from the group consisting of carboxyl, nitro, imide, epoxy, aldehyde, hydroxyl, amino and isocyanate; and with a proviso that Q is imide or epoxy, Q is directly bonded to Z or Q is indirectly bonded to Z via -OCO- or -0C0-(CH2)n-; n is an integer of 8-15; m is an integer of 0-10; -OCO- is Furthermore, this invention relates a solid substrate the surface of which is coated with the above-mentioned linkers, and a biochip comprising the solid substrate. |