| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e75810cb7d022e16fc3e012a68ae090
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1915fb9c2c4b338e964be39b8cf66209
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f59e6254d93cba01bcda1f69a9cc50e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95cd4f811d7b4d99e905ba9c9a77c863 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2007-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48fb846bd3de760f722aa9fc4dc3008e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_086d72e33734bb5636dedfc8fae61bf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8330dedbe07493909abbaa18fc13e42a |
| publicationDate |
2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008074131-A1 |
| titleOfInvention |
Skin and salivary tests for the detection of sensitivity to oxidative stress based therapies |
| abstract |
Radiation therapy (RTx) is standard treatment for prostate cancer (PC). Testosterone increases the basal cellular reactive oxygen species (bROS) levels resulting in a dose-dependent activation of phospho-p38, pAKT and increased expression of clusterin, catalase and manganese superoxide dismutase (MnSOD). These effects are reversible by androgen depletion (AD) or incubation with a reducing agent. Thus, testosterone induces a preset cellular adaptation to radiation through the generation of elevated bROS, which is overturned by AD. The present invention provides a minimally or noninvasive test for determining potential sensitivity to radiation therapy for hormone sensitive tumors; the test comprises measuring the level of basal or stimulated oxidative status of a hormonally regulated tissue and at least one oxidative stress adaptation marker. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2894477-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114870011-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018060741-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019521961-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011018090-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017196810-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11435341-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7170542-B2 |
| priorityDate |
2006-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |