http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008070647-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f87428a2ce83db0ea23b4ca28c5f3143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34949283c89ad74fecdb15c2fa47efbf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-5434 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-57 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2007-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cad848178c47b6269898eca25ecd8070 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f4bb9a764936a7d0cea1d7b5e4573b3 |
| publicationDate | 2008-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2008070647-A1 |
| titleOfInvention | Methods and compositions for assessing il-12 or the neutralization of il-12 in a sample |
| abstract | Methods for detecting the presence or amount of Interleukin-12 (IL- 12), particularly human IL- 12, or antibodies that neutralize the activity of human IL- 12 in a human biological sample, involve incubating the biological sample with an NK cell line or progeny thereof. A correlation is determined between the presence or amount of IL- 12 (or anti-IL-12 antibodies) in the sample and the amount of gamma interferon (or a precursor activation factor or cytokine) secreted by the NK cells. For measuring antibodies, the sample is pre-incubated with IL-12. Levels of a cytokine or activation factor, such as IFN-γ, secreted by the NK cells when in the presence of IL-12 are then compared with a control level of the cytokine or activation factor secreted by the NK cells or progeny thereof in the presence of a known amount of IL-12 and without the biological sample. The presence of IL-12 or neutralizing anti-IL12 antibodies in the sample is indicated by a variation, e.g., an elevation or reduction, in the level of the secreted cytokine or activation factor in the sample as compared to the control level. These methods are useful for monitoring or determining the presence of IL-12 in a sample or neutralizing antibodies generated to IL-12 when the IL-12 is delivered as a vaccine adjuvant and in clinical situations wherein IL-12 enhancement or diminution is involved, among others. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103370622-A |
| priorityDate | 2006-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 203.