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filingDate 2007-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bcb5c7bb7171b2f1183939f3812a2ee
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publicationDate 2008-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2008069938-A2
titleOfInvention Method of forming a tablet comprising pre-blend of ibupropen and silicon dioxide
abstract A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second mixing effort, resulting from mixing at least one excipient with the pre-blend mixture, form a blend suitable for direct compression and compressing the blend to form the tablet. One way of achieving the first mixing effort is to pre-blend for an extended period of time. The method allows for directly compressing the blend without the need for a granulation step or roller compression. One such active pharmaceutical ingredient susceptible to tackiness is ibuprofen.
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