| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d50a5d08fff80f620aa6f328cd9bc85e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1fb636826d1fab583ec10e9e1a8350d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfa3b5a741ebc973302c27d673ca6ac1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
| filingDate |
2007-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b50feb04fe2b47709d942ab610cf4c29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0d25d5afa6615269bb8892bb443ade3 |
| publicationDate |
2008-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008067495-A2 |
| titleOfInvention |
Chemotherapeutic conjugates and methods of use |
| abstract |
Chemotherapeutic conjugates of a peptide substrate to a phosphoramide chemotherapeutic agent in which a peptide substrate is covalently linked to the chemotherapeutic agent by a linker with an aminoarylmethyl or aminoheteroaryl moiety, wherein the linking of the peptide to the chemotherapeutic agent inhibits the cytotoxic activity of the chemotherapeutic agent, the peptide is a substrate for proteolytic cleavage by a tumor-specific enzyme; and the linker is capable of undergoing 1, 6-elimination in vivo upon cleavage of the peptide substrate. Methods for synthesizing and methods of using the conjugates are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9993514-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9988376-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10730862-B2 |
| priorityDate |
2006-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |