| abstract |
The instant invention provides methods and compositions for treating a subject suffering from an MITF associated disease, such as Microphthalmia, Waardenburg syndrome type 2a, Tietz syndrome, digenic ocular albinism, Sensorineural deafness, albinism, and osteoporosis. The invention also provides methods and compositions for modulating a function of MITF, inducing melanogenesis in a melanocyte or a melanoma cell, and sensitizing a melanoma cell to a chemotherapeutic agent. |