http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008063240-A9
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4877f0974f07e3c75db0c69e6697e80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_385cc0d0915157e10d912ef81a37d261 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_961c3d97d21f088cfebef5e26e5545e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3e70cef76067a6b4f83e62256cffdb7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b56fdf1622a810db2775b8629dc270cc |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 |
filingDate | 2007-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab9ac4919b1a14530148ab63fecc9816 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb204f86aab6cb7c3f1557098008a73c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3cac41ea4526365aa3809e8ced3cfa5 |
publicationDate | 2008-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | WO-2008063240-A9 |
titleOfInvention | Live bacterial vaccine |
abstract | The present invention relates, e.g., to a Lactobacillus bacterium, which (1) expresses a recombinant polypeptide containing a lipoprotein signal sequence from the OspA protein of Borrelia burgdorferi, or an active variant of the leader sequence, operably linked to one or more heterologous polypeptide(s) of interest and/or (2) which comprises an expressible polynucleotide encoding a recombinant polypeptide, wherein the polynucleotide encodes a lipoprotein signal from the OspA protein of Borrelia burgdorferi, or an active variant thereof, which is operably linked to one or more heterologous polypeptide(s) of interest. In one embodiment, the heterologous polypeptide is from Yersinia pestis, the etiologic agent of plague. In another embodiment, the heterologous polypeptide is from Borrelia burgdorferi, the etiologic agent of Lyme disease. Also described are immunogenic compositions, such as live bacterial vaccines, comprising the bacterium; methods for eliciting an immune response against the polypeptide using the bacterium; and kits comprising the bacterium. |
priorityDate | 2006-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 992.