| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75dc6c5a6a864c2c7a431255fdf8e848
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3c6f6ab0b69584e0bba483b29398a7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_175a7404a3663896c039927b31a8c2e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7da5c8e8c3e8261efe7e698c7198681b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2007-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5af1e6e7107eb42e41bbcd3b212d0cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_125307cf87ced235950fb2d995eccee2 |
| publicationDate |
2008-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008062091-A1 |
| titleOfInvention |
Use of non-human mammals lacking vav2 protein expression and/or activity in the cardiovascular, kidney and neurological fields |
| abstract |
The invention relates to the use of non-human mammals which have been genetically modified to eliminate the Vav2 gene and/or to reduce expression of the levels of its messenger RNA or of the protein that encodes the Vav2 molecule. This animal model, or cell lines derived therefrom, can be used in various types of experimental methods for the identification and characterization of drugs that can be used to prevent and/or treat diseases or disorders which are common in humans such as essential hypertension, cardiac and arterial hyperplasia, tachycardia, kidney failure and fibrotic processes. This model is also useful for the identification of genetic, biochemical, physiological and other kinds of markers which have prognostic value in poorly characterized human diseases such as those mentioned above. |
| priorityDate |
2006-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |