| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35ccfa4f2a128de421b0cf1e9fa17e9e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae6d890972bab0a62ed74e6707a23497
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f861d7dfdde7b233339d4838364a8e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee96068ff0420bfde113feb384eba257 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43518
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-64 |
| filingDate |
2007-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f1c50952e64602b47b997b5a0f3d4a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c08d0315792fa9b1a636aae9ad47c6d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b2af0f8db39c03cb5ac9ab9d5813e18 |
| publicationDate |
2008-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008061329-A2 |
| titleOfInvention |
PHα1B TOXIN, CDNA OF PHα1 B TOXIN GENE, PHARMACEUTICAL COMPOSITIONS CONTAINING PHα1B TOXIN, PROCESSES FOR THEIR OBTENTION AND PRODUCT |
| abstract |
Methods and compositions for blocking calcium channels with a spider toxin Phoneutria nigriventer are provided. For easy identification the toxin will be sometimes generally referred to as Phα-1B during the present description of the invention. The toxin comprises a 55-amino acid toxin having a molecular weight of approximately 6,017. This Phα-1B spider toxin was found to block calcium channels within the nervous system. The synthetic gene responsible for producing this toxin has been designed and cloned. This gene and/or its derivative provide a mechanism by which the toxin can be produced using recombinant DNA expression technologies. The present invention further relates to methods of treating neurological diseases and pain by applying the isolated and identified toxins. The toxin Phα-1B may provide beneficial effects on pain and certain neurological conditions including seizures, ischemic- hypoxic, CNS damage, and neurodegenerative disorders. It was also found that the toxins are effective as tags in probing calcium channels. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879060-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10485847-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10881712-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3187167-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017011863-A1 |
| priorityDate |
2006-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |