| abstract |
A pharmaceutical composition comprising a 1,4-dihydropyridine pharmaceutical agent, particularly (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate), a mixture of glycerol and PEG1500 esters of long fatty acids having a melting point of approximately 44 °C and a hydrophilic/lipophilic balance of approximately 14 (Gelucire 44/14) and d-alpha-tocopheryl polyethylene glycol 1000 succinate (Vitamin E TPGS), and further optionally comprising polyethylene glycol-15-hydroxystearate (Solutol-HS 15) and/or polyoxyl castor oil (Cremophor-EL), exhibits enhanced solubility characteristics. |