| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_115c4dec4bde5bfab8c813c0aa1ac5cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e8432ebff5a06ee8a6ffec8cc7611fbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e84cb6002fb18499ac6c633d535b9f72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c544d677469ada50ad203b85c1c2cf8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 |
| filingDate |
2007-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66dd13bbaac14b21ace96ac79e866c25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6089d9e30d755e2000b6e81857a7bb38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2d0518bfb53d47a72e5ea6db058c19a |
| publicationDate |
2008-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008056378-A3 |
| titleOfInvention |
Novel process for the preparation of naratriptan hydrochloride |
| abstract |
Present invention provides a novel and improved process for the preparation of N- methyl-1H-indole-5-ethanesulfonamide of formula (I). Compound of formula (I) is a key intermediate used in the synthesis of naratriptan hydrochloride of formula (II). Hydrazone derivative of formula (XL) derived from the corresponding hydrazine and pyruvate ester is reacted with an acid catalyst to get the indole-2-carboxylate derivative of formula (XLI). Hydrolysis of this ester and decarboxylation gave the compound of formula (I). Naratriptan hydrochloride (Amerge) is widely used as anti-migraine drug in the market. |
| priorityDate |
2006-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |