| abstract |
Process for the preparation of 2,5-bis(2,2,2-trifluoroethoxy)-N-(2- piperidylmethyl)benzamide, its pharmaceutically acceptable salts and important intermediates thereof that involves 1,4-dihalotoluenes as starting material. The method involves a technique for preparing the starting material 2,5-bis(2,2,2-trifluroethoxy)toluene in high yields by reacting 1,4- dibromotoluene with 2,2,2-trifluoroethanol in presence of a base and a copper-containing catalyst. |