http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008053136-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b13a186c49b545a92867e3b9ed28213a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4bb2b15ee842821e2028150cbf93813 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fe8398e628f5eba00bc7eae0a5f5c01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_134a9e77d22d33a235c17cd7e1cdb273 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 2007-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5498e03528383ba604a0ab061d2a54aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16790167fde22e398587ec24b4e56d18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c86c4340620715c6dd7bc682c064ce14 |
| publicationDate | 2008-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2008053136-A1 |
| titleOfInvention | 2-(hetero-)aryl,4-carbonyl substituted pyrazole derivatives as inhibitors of p38 mitogen-activated protein kinase |
| abstract | Compounds of formula (I) are inhibitors of p38 MAP kinase activity, and are useful in the treatment of, inter alia, inflammatory and autoimmune disease wherein Ring A is aryl, heteroaryl or heterocyclyl of 5-13 atoms; Ring B is optionally substituted aryl or heteroaryl of 5-13 atoms; Z is (a) a radical of formula -(CH2)z-X1-L1-Y- NHCHR1R2 or (b) a radical of formula -(CH2)z-Y1-L1-R wherein R1R2CHNH- and R are respectively N- and C-linked amino acid or amino acid ester groups as defined in the description, and -Y-L1-X1-(CH2)z- and -L1-Y1-(CH2)z- are linker radicals as defined in the description; R7 is hydrogen or -C(=O)R' where R' is hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl or (C1-C6)haloalkyl; R8 is hydrogen or (C1C6)alkyl; R9 is hydrogen, halogen, hydroxyl, (C1-C6)alkoxy, (C1-C6)alkyl; R18 is hydrogen, halogen, hydroxyl, (C1C6)alkoxy (C1-C6)alkyl, - NRaRb where Ra and Rb are hydrogen or (C1-C6)alkyl, or optionally substituted aryl, heteroaryl or heterocyclyl or Ra and Rb when taken together with the nitrogen to which they are attached form a cyclic amino group of up to 6 ring atoms; R19 is hydrogen, halogen, (C1C6)alkoxy, or (C1C6)alkyl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010097586-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112279813-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112279813-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11565994-B2 |
| priorityDate | 2006-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 499.