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publicationDate 2008-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2008050898-A1
titleOfInvention PARTIAL FRAGMENT OF REIC/Dkk-3 GENE AND THERAPEUTIC AGENT FOR CANCER CONTAINING THE SAME
abstract It is intended to provide a cancer cell apoptosis inducer containing a REIC/Dkk-3 gene fragment and a therapeutic agent for cancer containing the apoptosis inducer. The following (a) or (b) polynucleotide, which is a fragment of a polynucleotide encoding REIC/Dkk-3 protein and encodes a polypeptide having an apoptosis activity: (a) a polynucleotide encoding a polypeptide which consists of an amino acid sequence starting from an amino acid at position 1 and terminating at an amino acid at any position between position 39 and position 78 in the amino acid sequence of REIC/Dkk-3 protein represented by SEQ ID NO: 2; and (b) a polynucleotide encoding a polypeptide which consists of an amino acid sequence in which one or several amino acids have been substituted, deleted or added in an amino acid sequence starting from an amino acid at position 1 and terminating at an amino acid at any position between position 39 and position 78 in the amino acid sequence of REIC/Dkk-3 protein represented by SEQ ID NO: 2, and has an apoptosis activity.
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