http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008048773-A9
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85c05a815384a4fa2a533318637463e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3183345223c0c5b56782f14a9e6c0973 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1a4d350b0154931825ddbe233976df0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69b7717e8ef01f042de035cdaf0dfc58 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0362 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-40 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2007-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8913ffefdadc86d9029a9b382fe6d243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a47b2d2809e47e7b2bc556cc4aefd67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ede10fe7eb6a4e4ae97fb45a6323e71b |
| publicationDate | 2008-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2008048773-A9 |
| titleOfInvention | Models of atherosclerosis, hyperlipidemia, lipoprotein oxidation and blood vessel inflammation and methods for making and using them |
| abstract | The invention provides genetically altered fish of the family Cyprinidae, or genus Danio, including zebrafish (Danio rerio) and host cells from these animals, where the fish have been genetically altered to lack or have a modified gene related to lipid metabolism, for example, an ApoE, ApoAI and/or LDL-R gene. In another aspect, the invention is directed to drug design or discovery using the animal or cell models of the invention and/or wild type zebrafish, and by administering an altered diet and/or environment to the animal of invention. The invention also provides methods for screening for a compound capable of ameliorating or preventing or reversing: atherosclerosis; hyperlipidemia; lipoprotein oxidation; the accumulation of lipid in a blood vessel wall; vascular inflammation associated with lipid accumulation in a blood vessel wall; acute atherosclerosis-associated events; heart attack; stroke. |
| priorityDate | 2006-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 277.